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Creatinine and eGRF levels

Bigtex

Bigtex

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Aug 14, 2012
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Just a heads up to those of us having blood monitored. If you get back a high creatinine reading and/or a low eGFR reading do not be alarmed, you most likely do not have kidney problems. High protein diets, high amounts of muscle mass and taking creatine supplements will definitely cause this. As we know creatine come from the protein we eat, the muscles store it. Creatine degrades to creatinine, especially with intense lifting.

1 October 2009. Related: Conference reports, PK and drug interactions, Side effects, Lipodystrophy Workshop (IWADRW) 11 Philadelphia 2009.

Several case studies showing the impact of creatinine supplementation on eGFR results, were presented in a poster by Graeme Moyle, from the Chelsea and Westminster Hospital, London. Estimated GFR is now routinely included in renal monitoring using the MDRD calculation, which incorporates serum creatinine, together with age, sex and ethnicity

Six HIV-positive male patients (aged 25- 55) on stable HAART were referred to an HIV/renal clinic due to elevated serum creatinine (range 131-257 umol/L) and low eGFR. All had normal blood pressure and no history of diabetes. Proteinuria levels were normal and confirmed by urinary protein:creatinine ratio. Each patient routinely used protein and creatine supplementation as part of a muscle-building gym routine.

Three months after 5/6 patients discontinued the supplements, serum creatinine levels consistently dropped to between 98 and 118 umol/L and eGFR reported to normalise (eGFR data was not shown).

Although dietary intake of creatine is 1g/day, supplementation can increase this 20-30 fold, and intramuscular concentrations can remain elevated for several weeks. Creatine is converted to creatinine, relative to its concentration, which can increase serum creatinine, despite normal renal function. The poster suggested that ARV exposure may also be involved but also that the association of raised serum creatinine with creatine ingestion has not been published outside of the HIV context.

COMMENT

This study highlights the importance taking a history of supplement use to consider this as a cause for elevated creatinine or low eGRF.


Moyle G et al. The pitfalls of the estimated glomerular filtration rate – ‘hitting the gym and creatine supplementation’. 11th Intl Workshop on Adverse Drug Reactions. 26-28 October 2009, Philadelphia. Poster abstract P27. Antiviral therapy 2009; 14 Suppl 2: A49.


Here is another one

J. M. Schedel, M. Tanaka, H. Tanaka, A. Kiyonaga, M. Shindo, P. Terrier, Y. Schutz. Consequences of one-week creatine supplementation on creatine and creatinine levels in athletes' serum and urine

https://core.ac.uk/display/18159763

We found that 30g/day (!) of creatine intake increased significantly creatinine serum level from 1.20mg/dl to 1.46mg/dl. After one week wash-out, it goes down back to 1.23. Of course, this increase is for a much higher dose than the 5g/day that you mention
 
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