Coming off an Anti-E in a 60 yr old female BCa survivor

[Wilson6]

One of my female clients is a BCa survivor, cleared the 5 yr mark and was allowed to stop her anastrozole 6 mo ago. She is 60, I started training her right after her surgery. Sent her to Dr Glaser in Dayton OH where she started T with anastrozole pellets 3 yrs ago. She was about to quit the AI back then bc the side effects were terrible despite warnings from her oncologist. Her total T with pellet now ranges from about 600 ng/dl about 4 weeks after the pellet to around 250 ng/dl about 2 weeks before the next one (8-10 wks), so probably near 800 right after the pellet implant to about 200 just before. With the AI her E2 < 5 pg/ml, undetectable. The T + A resolved most of her menopausal Sx and sides of the AI with the exception of chronic wrist pain. The addition of T made dramatic changes in body comp (alot of muscle and 12% BF year round, esp in the legs and glutes). Glaser told her it would take 4 mo to start noticing life without an AI as the residual pellet lasts quite a while and very little ANAS is needed to crush E2. Over the past 2 months (now at 6 mo post AI) her wrist pain is gone, joints overall feel better, skin looks like she's 20, she has leaned out further and is harder and more muscular, has more energy and better mental clarity. She has changed nothing else (diet, training, etc.) other than drop the AI. E2 is slowly rising now from the aromatization of her T. Her Onco was opposed to the T the whole time. All her checkups have been good. Observational, but clearly she's doing better without the AI. The idea that she'd get fat, blow up with water, etc. simply is not happening with higher E2, in fact just the opposite. Something to think about.

 

[969C1]

One of my female clients is a BCa survivor, cleared the 5 yr mark and was allowed to stop her anastrozole 6 mo ago. She is 60, I started training her right after her surgery. Sent her to Dr Glaser in Dayton OH where she started T with anastrozole pellets 3 yrs ago. She was about to quit the AI back then bc the side effects were terrible despite warnings from her oncologist. Her total T with pellet now ranges from about 600 ng/dl about 4 weeks after the pellet to around 250 ng/dl about 2 weeks before the next one (8-10 wks), so probably near 800 right after the pellet implant to about 200 just before. With the AI her E2 < 5 pg/ml, undetectable. The T + A resolved most of her menopausal Sx and sides of the AI with the exception of chronic wrist pain. The addition of T made dramatic changes in body comp (alot of muscle and 12% BF year round, esp in the legs and glutes). Glaser told her it would take 4 mo to start noticing life without an AI as the residual pellet lasts quite a while and very little ANAS is needed to crush E2. Over the past 2 months (now at 6 mo post AI) her wrist pain is gone, joints overall feel better, skin looks like she's 20, she has leaned out further and is harder and more muscular, has more energy and better mental clarity. She has changed nothing else (diet, training, etc.) other than drop the AI. E2 is slowly rising now from the aromatization of her T. Her Onco was opposed to the T the whole time. All her checkups have been good. Observational, but clearly she's doing better without the AI. The idea that she'd get fat, blow up with water, etc. simply is not happening with higher E2, in fact just the opposite. Something to think about.

Wow! Thanks for sharing this. My wife is a breast cancer survivor. She is almost 7 years clear now. She was prescribe Nolva for 10 years at 20 mg per day by her oncologist. Going through chemo, it did push her into menopause a little earlier. She is 54 now. She started TC at 10 mg per week and has been now for 6 months. We also dropped her Nolva to half a tab per day. She too was experiencing tendon and joint pain. It has let up a bit since dropping the Nolva to 10 mg per day. We were thinking of dropping the Nolva altogether and substituting is with a very small dose of Mast for the AI purpose. If I am not mistaken from research, Mast was originally used for estrogen feed BC in women, but taking an oral was much easier for daily use, hence why most are now prescribed Nolva, (tamoxifen).

 

[myosin]

One of my female clients is a BCa survivor, cleared the 5 yr mark and was allowed to stop her anastrozole 6 mo ago. She is 60, I started training her right after her surgery. Sent her to Dr Glaser in Dayton OH where she started T with anastrozole pellets 3 yrs ago. She was about to quit the AI back then bc the side effects were terrible despite warnings from her oncologist. Her total T with pellet now ranges from about 600 ng/dl about 4 weeks after the pellet to around 250 ng/dl about 2 weeks before the next one (8-10 wks), so probably near 800 right after the pellet implant to about 200 just before. With the AI her E2 < 5 pg/ml, undetectable. The T + A resolved most of her menopausal Sx and sides of the AI with the exception of chronic wrist pain. The addition of T made dramatic changes in body comp (alot of muscle and 12% BF year round, esp in the legs and glutes). Glaser told her it would take 4 mo to start noticing life without an AI as the residual pellet lasts quite a while and very little ANAS is needed to crush E2. Over the past 2 months (now at 6 mo post AI) her wrist pain is gone, joints overall feel better, skin looks like she's 20, she has leaned out further and is harder and more muscular, has more energy and better mental clarity. She has changed nothing else (diet, training, etc.) other than drop the AI. E2 is slowly rising now from the aromatization of her T. Her Onco was opposed to the T the whole time. All her checkups have been good. Observational, but clearly she's doing better without the AI. The idea that she'd get fat, blow up with water, etc. simply is not happening with higher E2, in fact just the opposite. Something to think about.

E2 levels are slowly becoming less demonized and switching to what in hindsight what we should have been doing all along…
- what’s your level?
- what sides, if any, do you have?

Arguably E2 is the marker that is the most variable person to person… two people with the same levels can have such varied responses/sides.