I posted the recent clinical trial papers, can't remember which post but if you search you should find them. They are also on line, should be able to Google them and other papers related to the new 3 receptor drugs. Very interesting research should be the cutting edge weight loss drugs next in line. Still, while the general public abuses them, I believe much lower dosing combined with dietary discipline/exercise and with or without light PED use to maintain/increase lean will have the best long term outcome without excessive risk.