Bloodwork AST and ALT

[Chump]

Had a general physical back on June 9. Blood work showed elevated AST, ALT and Creatinine

I've been on a dermal cream TRT just over a year. My total has ranged from the 400-900. I did not apply the cream the morning before this blood test.

So, I informed my GP I was on TRT through on-line provider and he even offered to take over managing my TRT, which I will discuss with him at next appt. But his note to me about bloodwork was:

"Overall your lab work is stable, however your AST and ALT (liver enzymes) are elevated compared to the last check. This may be related to your testosterone replacement therapy. Please discuss this with the provider that prescribes your testosterone."

Could TRT have effect on these liver measurements?

 

[JackD]

What medication are you using for TRT? But typically no. Liver enzymes would be directly linked to some oral medication, alcohol use, or a disease… or all the above. What are you taking both OTC and other medications? Do you drink alcohol? Water consumption?

 

[Bigtex]

Elevated levels of ALT, AST, and creatinine can be influenced by high protein intake and high-intensity exercise. These levels can remain high for 7 days after intense workouts. High levels of muscle mass will also affect these levels.

 

[parttimer]

So, on a side note about lab tests, something I discovered last year. My GP would run my labs, or I got them from Private MD/labcorp, my AST/ALT was always through the roof. A few times I needed procedures done at the hospital. They would pull labs before the procedure and I'd be borderline normal on them. Sometimes the labs would be days apart from GP/Private MD and the hospital....

 

[Chump]

Thanks for all the feedback

@JackD I'm using Fountain TRT as my provider since Feb 2024. F-Testosterone Dermal Cream 200MG/ML. 4 clicks daily = 200MG Testosterone. As far as medications, I'm take the following daily:

Aspirin 81mg
Losartan 25mg
Metoprolol 75mg
Xarelto 20mg
Atorvastatin 80mg

Supplements:
Yohimbe 450mg
Magnesium 400mg
D3 1000 iu
K2 45 mcg
Creatine 5g

I do try to consume 200 g of protein/day, but quite honestly during the summer I'm pretty inconsistent with diet

@Bigtex I looked at my journal and I did do a pretty high intensity workout the morning of that blood test

I've been down the creatinine road before. Its always seems elevated and twice the GP has sent me to specialist and they've told me its due to higher muscle mass, higher protein diet

So, I've got a follow up with GP soon with regards to AST/ALT.

I've got a couple of appts lined up with local doctors GP, urologist to look into taking over my TRT

 

[Cohiba]

That's what my bloodwork looks like after a few months of anavar. Any other orals like dbol and it's way worse.

I don't see anything in your list that looks hepatoxic, so it may be worth checking into this more.

The whole excercise thing is a real factor also, but I wouldn't think it would thrown them off that much. BUT it could.

Another thing I've found is my numbers bounce back quickly. So I'm kind of sensitive to elevated ast / alt since something mild like anavar pushes mine, but once I'm off they're back down in a week.

I know this doesn't answer your qst but hopefully it helps.

 

[Bigtex]

Thanks for all the feedback

@JackD I

@Bigtex I looked at my journal and I did do a pretty high intensity workout the morning of that blood test

I've been down the creatinine road before. Its always seems elevated and twice the GP has sent me to specialist and they've told me its due to higher muscle mass, higher protein diet

So, I've got a follow up with GP soon with regards to AST/ALT.

I've got a couple of appts lined up with local doctors GP, urologist to look into taking over my TRT

Have your doctor run a gamma-glutamyl transferase (GGT) test. GGT is an enzyme found in liver cells, and its levels can indicate liver damage or inflammation, including conditions like hepatitis, cirrhosis, or tumors, it is not affected by resistance exercise,

 

[Chump]

Had bloods done last week and AST and ALT were back in normal range

Thanks for all the feedback

 

[The other Snake]

Elevated levels of ALT, AST, and creatinine can be influenced by high protein intake and high-intensity exercise. These levels can remain high for 7 days after intense workouts. High levels of muscle mass will also affect these levels.

Tex is right but those levels all together are concering. Any previous BW that would shed some light on this would help.

 

[luckysaint]

Whenever this happens to me and it has in the past I lowered my Protein intake a few days b4 going to the Doc and everything was normal... espeicailly with the Creatinine which they seem to think its god aweful if its over 1.3.. which is BS to me, but these Docs dont know everything! just do some research on whats off and you can fix on your own easily most of the time

 

[Wilson6]

One hard workout can raise ALT/AST significantly. ALWAYS get a CK measured with labs. If it is 10x+ UNL expect significantly elevated ALT/AST. ALT has a longer t 1/2 than AST and will remain elevated for 10 days after an eccentric bout of exercise. Repeated eccentric bouts will keep it elevated. I have never seen or read about any form of topical or non-C-17 testosterone ester raising LFTs. In Bhasin's studies 600 mg/wk of TC had no effect on LFTs and Amory et al 2006 gave TE orally 800 mg/d, decreased HDL, no effect on LFTs, same as Bhasin's 600 mg IM dosing.

 

[Saint]

I have no General MD, where's the best site to get blood work?