Best thermogenic supplement?

Discussion in 'Diet Pills & Supplements' started by DanButcher, Dec 16, 2012.

  1. DanButcher

    DanButcher Member

    Sep 9, 2010
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    2
    So whats the best thermogenic supplement peeps? Im not a big supplement person, so I need some enlightening.
    I bought a few Stacker IIs with stims and they work great before workouts, I dont know about how they will work with fat loss, since i just started taking them..

    Is Noexplode thermogenic?

    Thanks
     
  2. Stumpy

    Stumpy Olé, Olé, Olé VIP

    Sep 29, 2010
    2,266
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    Depends, are we talking over the counter supps or the ones that really do the job?
     
  3. GreatGunz

    GreatGunz VIP

    Jun 10, 2011
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    ^^^^^^^^ stump has a good question!
     
  4. upstatetank

    upstatetank Senior Member

    Dec 7, 2012
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    nothing wrong with a good ole fashioned ECA stack :)
     
  5. Littleguy

    Littleguy TID Board Of Directors

    Sep 30, 2011
    2,851
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    This is what I think is the best overall.:D
     
  6. Stumpy

    Stumpy Olé, Olé, Olé VIP

    Sep 29, 2010
    2,266
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    Same here.
     
  7. Times Roman

    Times Roman MuscleHead

    Oct 27, 2012
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    coffee................

    it's well understood, safe, and works
     
  8. StrongLyfe

    StrongLyfe Mr. Worxx

    Aug 25, 2012
    451
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    +1

    A Dunkin Donuts coffee with a Turbo Shot works well for me in getting going
     
  9. GreatGunz

    GreatGunz VIP

    Jun 10, 2011
    1,669
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    This is an old post but ultimately rotating with ECA-CLEN-ALBUTEROL IMO would be optimum on a 2 week schedule.
    This is long enough to start the process but not long enough to feel the effects fall off.
     
    SHINE likes this.
  10. SHINE

    SHINE MuscleHead

    Oct 11, 2010
    5,058
    601
    Albuterol does not share clens ability (or at least not to the same extent) to release NE, if I am interpreting it correctly.

    so you don't get the shakes as bad,


    Here is a study concerning Albuterol and subsequent apoptosis via B-1, in vitro.

    Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes.

    Zaugg M, Xu W, Lucchinetti E, Shafiq SA, Jamali NZ, Siddiqui MA.

    Department of Anesthesiology, Health Science Center at Brooklyn, State University of New York, USA.

    BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed to norepinephrine (NE) alone (10 mcmol/L) or NE+atenolol (AT) (10 mcmol/L) for 12 hours. AT, a beta(1)-selective AR antagonist, abolished the NE-induced increase in nick end-labeling (TUNEL)-positive cells compared with control (NE, 33+/-3% versus control, 3+/-1%, P<0.0001; NE+AT, 4+/-2% versus control, 3+/-1%, P=0. 98). Annexin V staining, DNA laddering, and caspase activity determinations corroborated these results. Subsequent experiments under prazosin treatment established the apoptosis dose-response curves for the increasingly beta(2)-selective AR agonists isoproterenol (ISO) (beta(1) approximately beta(2)) and Albuterol (ALB) (beta(2)>beta(1)). ISO and ALB induced significantly less apoptosis than NE (beta(1)>beta(2)) at equimolar concentrations as assessed by TUNEL staining [1 mcmol/L: NE (8+/-2%) approximately ISO (7+/-1%)>ALB (2+/-1%); 10 mcmol/L: NE (35+/-2%)>ISO (23+/-1%)>ALB (3+/-1%); 100 mcmol/L: NE (50+/-2%)>ISO (29+/-2%)>ALB (14+/-1%), P<0.0001 except for NE versus ISO at 1 mcmol/L with P=0.62]. ALB-induced apoptosis at 100 mcmol/L was abolished by AT (10 mcmol/L), indicating a beta(1)AR-mediated effect. Importantly, ICI 118551 (0.1 mcmol/L), a highly selective beta(2)AR antagonist, did not decrease the percentage of NE-, ISO-, and ALB-induced apoptosis. Reverse transcription-polymerase chain reaction studies revealed that AT completely reversed the beta-adrenergic signaling-induced changes in the Bcl-2-to-Bax ratio. CONCLUSIONS-These observations provide evidence that beta AR-mediated apoptotic death signaling is largely dissociated from beta(2)ARs and selectively mediated by beta(1)ARs in adult rat ventricular myocytes.

    PMID: 10899100 [PubMed - indexed for MEDLINE]
    1.


    cell apoptosis may be directly linked to taurine levels so keep taruine intake high ,Albuterol possesses the ability to cause apoptosis. Hell I don't need the studies for this I have real world experience but science is nice to lol. But it looks like Albuterol is safer for the heart and that's why the docs are using it rather than clen.

    AND due to the receptor desensitization and the long half life of clen. Since Albuterol has a shorter half life, one need not ramp it up as much as with clen, which translates to lower dosages for effectiveness. So yea Any alpha or beta agonist can potentially cause this, but I think the risks are minimized with shorter term use and especially with something like Albuterol which has a shorter elimination time. So yea Albuterol is a lot safer than clen IMO.

     
  11. SJA

    SJA VIP Member

    Feb 24, 2011
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    Is ephedrine a banned substance or not? I know they went back and forth for a while and I've seen it around but haven't kept track.
     
  12. PillarofBalance

    PillarofBalance Strength Pimp Staff Member

    Feb 27, 2011
    16,608
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    Banned as a dietary supp ingredient yea. Still sold in otc meds like bronkaid though.

    It's only bad for you if it's in a supplement apparently?
     
    SJA and Hero Swole like this.

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