Well.....AAS eventually shrunk my nuts, not that they were ever huge or anything, but at least now they are proportional to my tic-tac
I think as you get older, you eventually realize you are going to lose it in some places faster than others, and when it happens (either by age, genetics, or injuries), you still need to bust your ass, but at the same time with some acceptance. It seems this is mostly the case with areas like the quad sweep, calves, triceps, abs from aged loose skin, etc. I mean if quads are a genetic strong-point, it may not effect you as much, but it's something i've seen as guys get older.
Just wanted to point that out from an 'aged' perspective.
For a more direct answer, I used to be really proportional, but now my arms have shrunk from some shoulder injuries over the years (nerve damage?), and my quadsweep and overall size has went down. Part of this is that I train at home and don't have access to a leg press or hack squat or laying leg curl machine(s). I have a squat rack, but my back just can't handle the weight and pressure like it used to a few years back. I'm fine with that though. My arms are still decent, but I can tell a slight difference. I'm not a thick guy from back-to-chest though, so my arms do not look that bad. If you took both Ron Partlow and Dusty Hanshaw, i'd probably be almost identical to Ron (minus the quad tendon tears he had...ouch!).
I tore my right calve muscle back in 2013, so i'm disproportional now on those.