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Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC27068/
Agmatine is a novel polyamine that’s gaining recognition as a powerful ergogenic. It is formed within the body after L-Arginine interacts with the enzyme arginine decarboxylase. It acts as a neurotransmitter, a precursor to the polyamines and has many other key biological functions within the body.
Agmatine is an imidazoline receptor agonist. Imidazoline receptors have several functions: regulation of insulin secretion, pain modulation, and neuroprotection/neuromodulation. Clonidine, another imidazoline receptor agonist, has been noted to stimulate the release of luteinizing hormone (LH). Researchers conducted tests on agmatine and found that it can also modulate the release of LH from its interaction with hypothalamic tissues. The modulation of imidazoline receptors by agmatine has also been shown to improve insulin sensitivity.
Agmatine is also a positive modulator of the nitric oxide synthase (NOS) pathway. Nitric oxide synthases are a group of enzymes that produce nitric oxide from the amino acid L-Arginine. Increased nitric oxide results in vasodilation, which increases blood flow, nutrient delivery to skeletal muscle, and oxygen transport.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC27068/
Antagonists of glutamate receptors of the N-methyl-d-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting a clinical opportunity for the use of NMDAR antagonists and NOS inhibitors in chronic pain. Agmatine (AG), an endogenous neuromodulator present in brain and spinal cord, has both NMDAR antagonist and NOS inhibitor activities.
Agmatine is a novel polyamine that’s gaining recognition as a powerful ergogenic. It is formed within the body after L-Arginine interacts with the enzyme arginine decarboxylase. It acts as a neurotransmitter, a precursor to the polyamines and has many other key biological functions within the body.
Agmatine is an imidazoline receptor agonist. Imidazoline receptors have several functions: regulation of insulin secretion, pain modulation, and neuroprotection/neuromodulation. Clonidine, another imidazoline receptor agonist, has been noted to stimulate the release of luteinizing hormone (LH). Researchers conducted tests on agmatine and found that it can also modulate the release of LH from its interaction with hypothalamic tissues. The modulation of imidazoline receptors by agmatine has also been shown to improve insulin sensitivity.
Agmatine is also a positive modulator of the nitric oxide synthase (NOS) pathway. Nitric oxide synthases are a group of enzymes that produce nitric oxide from the amino acid L-Arginine. Increased nitric oxide results in vasodilation, which increases blood flow, nutrient delivery to skeletal muscle, and oxygen transport.
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