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A guide to GHRP's & GHRH's

AWARE72

AWARE72

MuscleHead
Oct 17, 2010
323
18
#1
This was a summary that someone I know wrote up on these peptides and there use.

1 - You are on this site because you have heard of and want to become more familiar with Growth Hormone Releasing Peptide (GHRP) and/or Growth Hormone Releasing Hormone (GHRH). These 2 materials administered can give you an increased quality of life in ways of anti-aging, muscular hypertrophy, fat loss, injury repair, higher bone density, and better sleep.

2 - GHRP can be used on its own to increase our natural Growth Hormone (GH) pulse release from the Pituitary Gland in the brain. GHRP dosed in conjunction with GHRH will amplify our growth hormone release significantly to gain maximal benefit.

3 - There are various types of GHRH's. The only GHRH to consider is tetra-substituted CJC-1295 / CJC-1295(without DAC) / modGRF(1-29). They are all the same thing but with a different name. They come in vials ranging in material weights measured in milligrams (mg) consisting of a solid freeze-dried (lyophilized) substance.

4 - There are various types of GHRP's. GHRP-6, GHRP-2, Hexarelin, and Imaporelin. The differences between them are potency and side effects. GHRP-6 is very potent, increases your hunger, and increases gastric motility. GHRP-2 is more potent than GHRP-6 and significantly increase GH release. Can slightly affect your sleep somewhat. Hexarelin is very potent but you can desensitize from higher dosages. Imaporelin is potent with the minimalist side effects of all 4 GHRP's.

5 - Peptides are dosed via a regular 1mL needle syringe typical to what a diabetic would use. It is administered Subcutaneously (SubQ) (just under the skin into the fat tissue),most usually around the abdomen region.

6 - The required amount (saturation dose) is 1mcg (microgram) per Kg (Kilogram) of bodyweight. The typical usage and for ease of measuring is 100mcg of modGRF(1-29) and/or 100mcg of your choice of GHRP. Lower dosages will simply result in less GH release due to a slightly weaker GH pulse and reduce any side effects you may have. A higher dose will have minimal benefit and is more a waste of money than anything else. But, in saying that, the more frequently dosed in any given day would result in more frequent pulses.

7 - Mixing (reconstitution) the lyophilized product in their vials with Bacteriostatic Water (BW) can take some getting used to. The idea is not to add too much dilution. Typical rule of thumb is to add 0.5mL of BW to 1mg of Peptide. So a 2mg vial should reconstitute with 1mL BW. 5mg with 2.5mL, 10mg with 5mL, etc. Squirt the BW along the inside wall of the vial in a smooth controlled manner being cautious not to agitate the mixture too much. It will dissolve itself and become clear. You can roll the vial gently between your fingers or hands but don't shake it to dissolve. The reconstitute is ok to be drawn once fully dissolved.

Peptide Calculator

8 - On a 1mL needle, there are either 50 tick marks from 0-100, skipping every odd number OR 100 international units (IU). A 100mcg dose is half way between the 2nd and 3rd tick mark, OR 5 IU's (if you followed the above reconstitution). There are no half tick marks. It is OK to draw modGRF and GHRP into the one needle for a single shot. It is NOT OK to mix peptides in the same vial or syringe for storage.

9 - Reconstituted peptide should be stored in the refrigerator to prevent degradation. Left at room temperature, peptide will degrade within days but kept in the fridge will last months. You can pre-load syringes and store in freezer if you want but it is more of a hassle than being worth the effort.

10 - Doses can be taken throughout the day but at no less than 3 hour intervals between doses. 1 dose a day is typical for light injury repair, anti-aging effects, deeper sleep, and better quality of life. The most beneficial would be to dose immediately prior to going to bed for your daily sleep period. Sleep is the time when our pituitary is most active. 2 or 3 doses per day will give the added benefit of lean tissue build, and fat loss, considering your diet consists of good quality foods.

11 - Doses should be taken on empty stomach to benefit the most. This is usually 3 hours or more.

12 - Do not consume food for 30 minutes after your dosage. GH pulses should peak within about 30 minutes in the young and 35 mintues in the older after dosage. Fats and Carbohydrates affect the pulse dramatically. Protein has no effect on pulse and you can have a pure protein source in your stomach at anytime if you so choose to.

13 - Dosage timing can be beneficial to your goals. For muscle growth, the 2nd most beneficial time to dose is post workout (PWO). Best time is pre-bed because sleep is when we recover and our cells repair and grow. Within 30 minutes should be fine but sooner the better. Remember to have your meal 20-25 minutes after dose.

14 - For fat loss, your supplemental dose is 1 hour pre-cardio exercise after a long fasting without food. Best time is after waking up and before breakfast. During cardio exercise, maintain a moderate intensity for between 30-60 minutes. 45 minutes is a good session. You do not want to go too hard or too long. A moderate pace will utilize Free Fatty Acids (FFA) at the highest rate for energy. Refrain from eating for approximately 2 hours after your exercise because this is the time the body is still burning fat as fuel. You must eat throughout the day to reduce the chance of muscle catabolism (breakdown).

15 - These Peptides can be used on a daily basis for the rest of your life without any harm. Enjoy!!!"
 
Last edited:
AWARE72

AWARE72

MuscleHead
Oct 17, 2010
323
18
#3
I can not take the credit for the write, however your right is a great summary for the persons just looking into these peptides...
 
chicken_hawk

chicken_hawk

MuscleHead
Oct 28, 2010
718
146
#4
I think peptides bring a lot of bang for the buck, but it surprised me of how many guys do not realize the synergy from using both GHRH and GHRP together.

Hawk
 
bigrobbie

bigrobbie

MuscleHead
Sep 19, 2010
509
143
#5
Thank's for a good post, and thank's again for being honest and not taking credit for another persons document...that shows great personal character.
 
truewealth

truewealth

New Member
Apr 21, 2011
2
0
#7
I have a question. I heard that that GHRH CJC-1295 has a long half life of like a week and daily injection is not necessary. But the peptides are a different story, since their half life is only like 30 minutes or so..

So my question is if I wanted to run CJC-1295 and GHRP-2 together what would the dosing schedule be? Do you recommend them both being shot together daily?

Thanks
 
J

Jeton

Member
Oct 6, 2010
23
0
#8
i'm a month into injecting tesamorelin daily at 2.2 milligrams n want to both bulk AND cut with it...i get it by rx for my lipodystrophy. cubby on Meso advised adding ghrp=6 to it, but i'm concerned about GH-related side effects if my GH-pulse is too great...diabetes and significant joint enlargement would really suck given everything else i have to deal with.

also, i've read that John Crisler prescribes GHRP-6 as a supplement, meaning no Rx required by law. besides safety, i'm concerned about legality for personal reasons.
 
J

Jeton

Member
Oct 6, 2010
23
0
#9
in terms of dosage, i was thinking 166 mcg's daily would be a conservative boost to GH-release as well as ghrelin-stimulus, and would also nicely put 5mg vials on a 30-day schedule.
 
AWARE72

AWARE72

MuscleHead
Oct 17, 2010
323
18
#10
I have a question. I heard that that GHRH CJC-1295 has a long half life of like a week and daily injection is not necessary. But the peptides are a different story, since their half life is only like 30 minutes or so..

So my question is if I wanted to run CJC-1295 and GHRP-2 together what would the dosing schedule be? Do you recommend them both being shot together daily?

Thanks
I currently use Mod GRF(1-29) and GHRP2 dose @ 100mcg upon waking, PWO, and prebed. By combining GHRH and GHRP you will have synergistic effect, As for GHRP yes the pulse of GH will start dimish after 30mins, when you add in the Mod GRF(1-29) you increase the spike of GH.
 
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Get Some

Get Some

MuscleHead
Sep 9, 2010
3,441
640
#11
The synergistic effect is achieved because GHRP's and GHRH's have different functions. One increases the number of GH releasing cells in the pituitary (a form of upregulation) and the other increases the amount secreted by each cell.

While exogenous GH suppresses your natural output, peptides increase your natural output via synthentic products. I really think that exogenous GH will fall out of favor and peptides will be the future for anti-aging. Far less side effects and the cost is more reasonable.
 
AWARE72

AWARE72

MuscleHead
Oct 17, 2010
323
18
#12
The synergistic effect is achieved because GHRP's and GHRH's have different functions. One increases the number of GH releasing cells in the pituitary (a form of upregulation) and the other increases the amount secreted by each cell.

While exogenous GH suppresses your natural output, peptides increase your natural output via synthentic products. I really think that exogenous GH will fall out of favor and peptides will be the future for anti-aging. Far less side effects and the cost is more reasonable.
Someones been doing some research! :)
 
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