For a good 20 years I've been splitting up quads and hams/calves into 2 workouts, hitting each once a week (or slightly less). When I started training 30 years ago, my legs were like toothpicks. They soon became my best bodypart.
I reached a point in my mid to late 20's where I could not do my entire lower body justice doing all 3 muscle groups together, and I was frankly having a very hard time completing such a workout. I was able to train each of the 3 muscle groups with greater intensity and volume by splitting them up, and my legs became much bigger and better over time.
Maybe consider trying hams/calves on Monday, upper body maintenance on Wednesday, and quads on Friday?
I will typically do 8-10 sets of various leg curls for hams (mostly 8-10 reps per set), and I also do some form of deadlifting roughly twice a month. I do 10-12 total work sets for calves (standing, seated, donkey) using moderately heavy weights, short rest periods, and a full ROM.
For quads I typically do at lest 5-6 sets of full squats for 6-15 reps, 3-4 sets of plate loaded machine squats for 6-15 reps, and several sets each of leg presses and hacks for 8-15 reps. I may occasionally do a final set of 20-30 reps of squats with a lighter weight at the end of the workout for a goof. I try to finish quads in under an hour. After 12-15 such work sets for quads I am totally whipped.