Me and my wife we been using Rips for 2 years, I'm on 4-6ius 5 days on and 2 off I tried going higher but I can't function at all, staying awake is the hardest part for me, including the use of Pharma grade T-4 has helped a little but still I feel the same sides, my wife uses 2iius 5 days on and 2 off and she feels the same way, the water retention went away already, I think it took like 6-7 months to my body to get use to it. I never used Pharma grade I might give it I try to compare sides.